Overview
bit.bio is an award-winning spinout from the University of Cambridge. Our breakthrough technology combines synthetic and stem cell biology for the precise, efficient and consistent reprogramming of human cells used in research, drug discovery, and cell therapy. At bit.bio, we are passionate about engineering human cells that will enable the medicine of the future. To do this we need talented and curious people who want to make an impact on the future of science and therapeutics.
As a team of individuals, we value science, collaboration, openness, curiosity and creativity. We are united by trust and respect for each other.
Location: Babraham Research Park, Cambridge
Type: Full time, permanent
Start: Immediate
This role does not meet the minimum salary requirements for UK skilled worker sponsorship. Candidates must already have the right to work in the UK or must not require sponsorship for a Skilled Worker visa.
Your role in our team
We are looking for a skilled research assistant with expertise in next-generation sequencing (NGS) to drive and enhance NGS workflows at bit.bio. You will apply your molecular biology experience including library preparation, sequencing, cloning and genotyping to deliver high-quality results, optimise processes and implement robust quality controls. Collaborative across teams, this key role will have a strong focus in enhancing bit.bio’s NGS capabilities and supporting the organisation’s scientific goals.
Your key responsibilities
* Manage a diverse portfolio of projects related to NGS deliverables including, single-cell omics, RNA-seq, Illumina and long-read sequencing, ensuring adherence to minimum Quality Control (QC) metrics and maximum turnaround time (TAT).
* Provide cross-functional molecular biology support as needed for vector design and a range of genotyping techniques.
* Ensure operational cohesiveness with comprehensive and robust documentation for work instructions, risk assessments, COSHH and ELN templates are robust and maintained.
* Contribute to broader scientific and operational strategies through active involvement in key committees, with a specific emphasis within the Department of Functional Genomics.
* Serve as a crucial intermediary between scientific, commercial, and manufacturing divisions to facilitate technology development and application.
* Have a Bachelor’s degree in a relevant field of Biological Science (or equivalent experience).
* Have the ability to operate autonomously with minimal, high-level direction.
* Must be able to manage multiple concurrent projects effectively, whilst maintaining adherence to defined turnaround times (TAT).
* A meticulous approach and attention to detail are required.
Essential experience
* Have proven experience in a Next-Generation Sequencing (NGS) focused role within the life sciences industry.
* Demonstrable experience in a wide range of Next-Generation Sequencing (NGS) library preparation methodologies, including single-cell omics (e.g., 10x Genomics, Parse Biosciences), bulk RNA-sequencing, and automated NGS processes.
* Substantial experience in nucleic acid extraction (utilising both column-based and/or automated systems) and subsequent QC, with a critical focus on assessing quality for downstream library preparation (proficient use of Agilent Bioanalyzer, TapeStation, and Qubit systems is required).
* Comprehensive experience with molecular biology techniques, including, but not limited to, PCR, qPCR, ddPCR, molecular cloning, and standard genotyping methods.
* Demonstrate proficiency in maintaining meticulous records (ELN).
Additional desirable capabilities
* Experience operating Illumina and Oxford Nanopore sequencing platforms.
* Proficiency with programming languages (e.g., R, Python).
* Capability to conduct risk assessments, including those under the Control of Substances Hazardous to Health (COSHH) regulations.
* Demonstrates an awareness of the current scientific literature, with a focus on emerging state-of-the-art NGS techniques.
More reasons to join us
bit.bio provides a vibrant and dynamic work environment in an exciting, fast-moving time for biology. We work with cutting edge technologies and with our world-leading scientific advisory board. We conduct pioneering work with real-world impact.
We trust our people to make significant contributions early on with opportunities to be involved in projects that are key to the success and growth of our young company. We invest in people, creating opportunities for personal development in an inclusive multi-skilled team with ambitious goals that provide opportunities to learn on the job from each other.
Creativity and open minds are encouraged for everyone to contribute to the success of the company.
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