About Healx
Healx is an AI‑powered tech bio company redesigning drug discovery. With over 10,000 rare diseases affecting 400 million people worldwide, 90 % of patients lack approved treatments. Our mission is to pioneer a new generation of drug discovery to bring treatments to patients faster.
The Role
We are seeking a Translational Scientist (DMPK & Safety) to bridge AI‑driven drug predictions with clinical reality. This drug‑centric, highly collaborative role combines data generation and interpretation with shaping the non‑clinical path to the clinic. You will sit within our pharmacology team while working closely with tech, curation, and clinical teams to translate computational predictions into viable therapeutic candidates.
Key Responsibilities
* Study Design & Oversight: Provide technical peer review for DMPK and safety in vitro and in vivo study designs. Refine protocols to generate gold‑standard, actionable data.
* CRO Management: Act as the technical lead for external research partners and CROs.
* Data Reporting: Synthesise chemical, pharmacological, and PK data into high‑quality summary reports and pre‑clinical dossiers.
* Drug‑Centric Translation: Contribute technical expertise to develop an appropriate Target Product Profile (TPP) and align discovery programmes to long‑term patient needs.
* Strategic Triage: Support the Project Leader and pharmacology team in reviewing AI‑generated drug predictions, using DMPK and safety knowledge to identify the candidates most likely to succeed clinically.
* Cross‑Functional Connectivity: Bridge pre‑clinical, tech, clinical, and commercial teams, providing insights on safety liabilities, drug exposure, and population suitability.
* AI Impact: Proactively seek opportunities to use AI and advanced computational tools to generate and refine DMPK and safety knowledge.
Success Criteria
* Integrated Decision‑Making: Act as a trusted partner across teams, aligning scientific and strategic perspectives.
* High‑Quality External Delivery: Ensure CROs and partners consistently deliver strong, actionable data under your guidance.
* Knowledge Sharing: Contribute to a collaborative environment where decisions are grounded in robust DMPK and safety insights.
What We Are Looking For
* Experience in DMPK within biotech or pharma.
* Strong expertise in DMPK modelling (e.g. Phoenix WinNonlin or similar tools).
* Ability to integrate diverse datasets into clear scientific narratives.
* Experience using Electronic Lab Notebooks (ELN) and preparing technical reports and pre‑clinical dossiers.
* Strong literature and database mining skills, particularly for safety data.
* Experience or strong interest in interpreting non‑clinical safety and toxicology data.
* Familiarity with evaluating toxicology packages and identifying dose‑limiting toxicities.
* Experience in oncology and/or neurology is advantageous.
Working at Healx
Healx operates a hybrid working model with a modern Cambridge office. For this role, we ideally seek at least one day per week onsite. We offer flexible working arrangements, including part‑time options, to support individual needs and business goals. The team is collaborative, supportive, and committed to personal development and meaningful impact.
What’s On Offer
* Competitive salary, share options, 7 % employer pension contributions, life insurance of 4 × base salary.
* Private medical insurance, 25 days annual leave (plus bank holidays) with the option to purchase additional days.
* Flexible and remote working options, home office set‑up allowance, and periodic in‑person team days.
* Enhanced family leave policies and flexible working practices.
* Personal learning and development budgets, regular career support.
* Opportunities to engage with rare disease patient communities and one paid volunteering day per year.
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