Job Description
An exciting opportunity has arisen for a Protein NMR Spectroscopist to join our client; a leading drug discovery organisation focused on developing therapeutic solutions for oncology and CNS disorders.
In this position, you will play a key part in supporting a fragment-based drug discovery (FBDD) platform, using advanced NMR techniques to investigate protein–ligand interactions and drive early-stage drug discovery projects.
Key Responsibilities
* Develop and optimise protein- and ligand-observed NMR assays
* Conduct NMR-based fragment screening campaigns
* Characterise hits and generate data on binding affinity, kinetics, and mechanism of action
* Prepare isotopically labelled protein samples (expression & purification)
* Analyse and present data to multidisciplinary project teams
Key experience:
* Strong expertise in protein NMR spectroscopy; either from academia or industry experience
* Experience of troubleshooting & maintaining NMR spectroscopy instruments
* Solid understanding of protein–ligand interactions and biophysics
* Ability to work independently and communicate effectively within cross-functional teams
* Fragment-based or structure-based drug discovery experience is desirable
* Experience with other biophysical techniques such as SPR, ITC, MS is desirable
3 year FTC