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Research assistant - lysosomal dysfunction in parkinson's disease

Oxford
University of Oxford
Research assistant
Posted: 18 August
Offer description

We are seeking

a Research Assistant neuronal cell biologist to join our team working on a translational research project investigating lysosomal dysfunction in Parkinson’s disease. The ideal candidate will have hands-on experience with induced pluripotent stem cell (iPSC) cultures, a strong background in cellular neuroscience or molecular cell biology, and a meticulous approach to experimental work and data handling. In this role, you will be responsible for developing novel biomarkers, testing therapeutic compounds, and contributing to assay development using iPSC-derived dopamine neurons from Parkinson’s patients. This post is available immediately until 30 June 2026. This project is funded by the Michael J Fox Foundation and conducted in collaboration with EndLyz, a new company within the Dementia Discovery Fund (DDF) portfolio—offering a unique opportunity to work at the interface of academic research and pharmaceutical discovery. Key responsibilities: • Undertake laboratory experiments and interpret data • Conduct imaging analysis and study assay read-outs of endolysosomal dysfunction • Generate and study iPSC-derived neurons and cell lines • Prepare data for publication and presentation • Contribute to wider project planning and methodology development • Collaborate across academic and industry teams to advance biomarker discovery
Selection criteria: • BSc/MSc in a relevant area of research (or near completion) • Practical experience with iPSC cultures • Knowledge of cellular models of neurodegenerative disease • Ability to innovate and troubleshoot technical problems • High attention to detail in experimental work and record keeping • Strong understanding of neuronal phenotypes and molecular cell biology
What we offer: Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including: • An excellent contributory pension scheme • 38 days annual leave • A comprehensive range of childcare services • Family leave schemes • Cycle and electric car loan schemes • Employee Assistance Programme • Membership to a variety of social and sports clubs • Discounted bus travel and Season Ticket travel loans While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

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