At Cancer Research UK, we exist to beat cancer
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Wehave an exciting opportunity for twoSenior Scientistsin smallmolecule protein sciences to join Cancer Research Horizons in our Glasgow lab.You’lllead the expression, purification and QC of protein antigens and related molecules,all ofwhichplay a criticalrole indriving our screening and crystallography programmes.
Workingprimarilyacross bacterialandinsect systems,you’lldeliver highquality, wellcharacterised proteins using a range of biochemical and biophysical methods.You’llcollaborate closely with multidisciplinarydrug discoveryteams, communicate insights clearly,drive strategic decisions, innovate across the existing pipeline,bring strong scientific leadership the team,andhelp ensure a safe, efficient lab environment.
We’relooking for candidates with a PhD (or equivalent experience) in Molecular/Protein Sciences, Chemistrywithsubstantialdrug discoveryexperience, with strong proteinproduction,purification, analytics, and molecular biologyexpertise.This is a high impact role that advances our discoveries. Ifyou'readaptable, driven, and ready to make a scientific impact, this is your chance to contribute.Every role at CRH is united by a single mission: beating cancer sooner. We carry out work that matters-impactingpatients, families, and the future of science.
About Cancer Research Horizons
As the world’s biggest medical research charity, we’ve helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.
We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK’s established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK’s world-class academic network, cutting edge technology platforms and clinical expertise to 1)Bring new treatments to patients faster and 2)Tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.
Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University,you’llbe joining over200 staff from both industrial and academic backgrounds, all dedicated to bringing forward the day we cure cancer.
What willyoube doing?
1. Expression and purification of recombinant proteins using bacterialandinsect systems to support screening and crystallography programmes– experience of mammalian protein expression would also be desirable
2. Ensure all production is sufficiently characterised and QC’d using appropriate biochemical and biophysical methods
3. Interpret,analyseand clearly summarise data for presentation to varied audiences
4. Work collaboratively within multidisciplinary research teams
5. Communicate effectively,demonstratingopenness and respect for others’ perspectives
6. Prioritise workload according to projectobjectivesand take responsibility fortimelydelivery
7. Drive scientific and technical innovation, including through internal and external collaborations, while staying current with developments in the field
8. Maintainaccurateanduptodateelectronic laboratory notebook records
9. Take responsibility for assigned laboratory equipment and associated duties
10. Uphold safe,compliantand effective working practices
Whatare we looking for?
11. PhDor equivalentin Molecular Sciences, Protein Sciences, Chemistry or significant experience within a drug discovery environment
12. Significant experience in providing protein & molecular biology expertise to enable drug discovery projects
13. Desire and ability to work in a fast-paced, quickly changing environment, showing agility/flexibility to meet deadlines and goals with a can-do attitude
14. Use of current molecular biology techniques (PCR, cloning) to construct expression vectors and isolate genes
15. Purification of tagged and native proteins via manual, AKTA and automated purification platforms using a range of chromatographic techniques
16. Production of cell-based targets and experience of tissue culture and the generation of transgenic cell lines
17. Protein analytical techniques – e.g. protein quantitation assays, SDS-PAGE analysis, HPLC, Western Blotting and protein modifications e.g. biotinylation
18. Track record of delivering results across a diverse project portfolio by leading and driving strategic and scientific initiatives
19. Production and purification of scFv fragments and IgG for screening in biochemical HTRF and cell-based assays
Our organisation values are designed to guide all that we do.
Bold: Act with ambition,courageand determination
Credible: Act with rigour and professionalism
Human: Act to have a positive impact on people
Together: Act inclusively and collaboratively
We’relooking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.
Ifyou’reinterested in applying and excited about working with us but are unsure if you have the right skills and experience,we’dstill love to hear from you.
What will I gain?
We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.
You can explore our benefits by visitingourcareers web page.
How do I apply?
Weoperatean anonymised shortlisting process in our commitment to equality,diversityand inclusion. CVs arerequiredfor all applications; but wewon’tbe able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.