If you are a creative scientist interested in collaborating across biophysics, structural biology, and biochemistry, then join us. Our labs (Pombo-Garcia & Wu) focus on the molecular organization of cell interfaces in epithelial tissue and glycobiology. We utilize super-resolution STED microscopy, CryoET, combined with biophysics and chemical biology, to study how epithelial cells organize in space and time under various physico-chemical conditions, driving self-organization processes like condensates that shape mesoscale structures essential for tissue function. As a Postdoctoral Researcher at the Rosalind Franklin Institute, you will contribute scientific expertise to a specific project or bring independent, innovative science to a team effort. This role offers opportunities to develop scientific independence, leadership skills, and an external reputation. Your main task will be to lead a project on developing tools for quantitative imaging of epithelial cell biology and biophysics, including supporting and developing workflows for bioimaging analysis using super-resolution STED microscopy, FLIM, FRET, and FCS. You will focus on creating visualization tools for biomolecules (lipids, glycans, proteins) to observe the dynamic formation of cell interfaces in epithelia, analyzing complex data from super-resolution fluorescence and CryoET. The role encourages broad experimental and analytical interests, contributing to new methods development and their application in studying cell interface organization and dynamics. Responsibilities also include: Planning and conducting experiments, analyzing results, and delivering scientific outputs. Collaborating within a project team on Franklin's Challenges. Leading research outputs such as publications, patents, and presentations. Supporting and supervising students or visitors. Progressing towards scientific independence and developing skills. Engaging in collaborations and expanding professional networks. Communicating effectively within research contexts. Developing search and discovery skills. Candidates should hold a PhD in cell biology, biophysics, or biochemistry, with experience in advanced quantitative microscopy analysis. Strong organizational and communication skills, laboratory experience, and the ability to formulate research questions are essential. The role involves leading publications, contributing to grant writing, and collaborating with the lab to advance knowledge. This position is ideal for someone with a background in quantitative imaging biology, biophysics, or in vitro reconstitution, aiming to lead projects on developing novel imaging tools to study biomolecules at cell-cell interfaces, and gaining experience with cutting-edge techniques like super-resolution imaging, condensate biology, and CryoET. We welcome applicants regardless of whether they meet every listed requirement, emphasizing our commitment to diversity and inclusion. Candidates close to completing their PhD may be considered with an initial salary of £37,500, increasing upon completion of their doctoral qualification. In return, we offer: 25 days holidays plus bank holidays and Christmas shutdown Generous pension scheme (up to 18% employer contribution) Group Life Assurance State-of-the-art laboratories in a hub building Hybrid and flexible working options Training and development opportunities Transport discounts and campus amenities Employee wellbeing support On-site parking, canteen, and food outlets Location in scenic surroundings with social and sports clubs The Franklin Institute values diversity and strives to create an inclusive environment, making accommodations for candidates with specific needs.
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