Site Name:
UK – Hertfordshire – Stevenage, Singapore – Jurong
Posted Date:
Apr 22 2026
Engineering Platform Lead – Oligonucleotides
Robust, scalable manufacturing platforms are essential to delivering high‑quality clinical and commercial oligonucleotide products. Our focus is on deploying GMP‑compliant, fit‑for‑purpose technologies across our internal manufacturing network and external partners to enable reliable scale‑up, seamless technology transfer, and cost‑effective commercial supply.
The Engineering Platform Lead resides within Process Technologies, Medicinal Global Clinical Manufacturing Organisation (GCMO), and acts as a platform engineering and GMP subject‑matter expert, following products and processes across the end‑to‑end development and manufacturing lifecycle. The role ensures product and process quality, reproducibility, scalability and long‑term manufacturability.
Responsibilities
* Ensure that appropriate platforms are used for GMP clinical trial material manufacture with scalability, manufacturability and commercial manufacture in mind.
* Provide technical expertise and lead aspects (project definition, equipment selection, procurement and commissioning / qualification) of internal GMP platform capital projects.
* Transfer platform knowledge as required to and from CMOs – including the support of assets that have been acquired or licensed as well as those arising from internal discovery programmes.
* Represent CM&SC in terms of platform stewardship and collaborate with Drug Substance Development, Drug Product Development, GCMO Pilot Plants, CMOs and MSAT and GSC Manufacturing Sites.
* Support the generation and maintenance of own and maintain product and process knowledge throughout the entire development life cycle, bridging Research / Early Development and Commercial Manufacturing Operations.
* Embed QbD, QF, PDVS, and GMPs in the GMP manufacturing network, ensuring quality is respected while speed and agility are retained by aligning product development strategies with these key initiatives.
Basic Qualifications & Skills
* Bachelor’s degree in chemical engineering, mechanical engineering, chemistry, bioengineering, pharmacy or other relevant discipline + experience in pharmaceutical manufacture and/or development.
* Experience with GMP manufacturing in small molecule drug substance, biological drug substance and sterile manufacturing operations across clinical and commercial manufacture.
* Experience of process design, quality / GMP, project management, equipment maintenance and design in a pharmaceutical setting.
* Experience collaborating with cross‑functional teams in a multicultural environment. Preparing and delivering written and verbal communications in a professional setting.
* Experience in leading a large matrix international organisation, building successful collaborations within and outside GMP manufacturing.
* Ability to work independently and set your own direction.
Preferred Qualifications & Skills
* Master or PhD in chemical engineering, mechanical engineering, chemistry, bioengineering, pharmacy or other relevant discipline.
* Would be advantageous to have manufacturing, scale‑up or development experience of oligonucleotide or peptide manufacture, and enzyme reactions.
* Matrix management, communication, synthesis and analytical capacity, presentation skills, spoken & written English, influencing, and flexibility.
* Experience in facility design, equipment procurement, capital projects, facility qualification and commercial manufacture are highly desirable.
* Solid understanding of regulatory requirements and the GSK QMS.
* A solid understanding of the connections with key stakeholders (clinical, regulatory, drug substance and drug product development, CMC project teams and GCMO, CSC and GSC groups) is considered an advantage.
Benefits
Competitive salary, annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, shares and savings programme.
Closing Date for Applications
7th May 2026
Equal Opportunity Employer
GSK is an equal opportunity employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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