Are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
Key Responsibilities
* Contribute to analytical program strategies across our therapeutic project portfolio, representing analytical development within cross‑functional project teams, providing strategic support and technical consultancy; develop and qualify analytical methods for biopharmaceutical process analysis and process‑related impurity testing, including host cell protein ELISA, 2D Western blotting, host cell DNA and/or endotoxin assays, and HPLC of residual impurities.
* Contribute to the development and control of critical reagents for biopharmaceutical assays; oversee technical transfer and validation of assays at contract manufacturers in line with ICH regulatory guidelines; develop phase‑appropriate specifications; contribute to relevant sections of CMC regulatory documentation (e.g., IND, IMPD, BLA, MAA) and help respond to agency questions.
* Lead, mentor, and develop scientists of lower grades within the analytical development team; prepare reports and presentations of high quality suitable for internal and external audiences; independently conduct investigations, propose new experiments based on emerging data, and provide technical support to others.
* Establish priorities for individual and team‑based projects; make decisions on prioritisation based on overall goals of the team, department and project, using direct evidence and personal experience as guidance.
* Share knowledge with the wider team and across departments, representing the department both internally and externally; increasingly analyse new techniques and theories from outside the company to advance workplace practices, sharing findings with leaders.
* Maintain laboratory records ensuring they are up to date, timely and meet correct standards; provide technical guidance on laboratory equipment use and recommend acquisition of new equipment; adhere to safe working practices in laboratories per Immunocore EHS policies.
Experience & Knowledge
* Essential: experience developing methods for analysis of recombinant proteins or antibodies; worked in a biopharmaceutical laboratory environment; hands‑on expertise with SDS‑PAGE, Western blotting of proteins and impurity testing (host cell protein ELISA, host cell DNA (qPCR), endotoxin, process residuals).
* Experience within early and late‑stage/commercial biopharmaceutical drug programs.
* Presented detailed scientific findings to internal and external audiences; mentored and coached less experienced colleagues in scientific practices and theory.
* Desirable: experience with HCP coverage assessments and strategy; knowledge of GMP; experience managing analytical activities at contract manufacturers.
* Led a small project team, formally or informally, through a change in practice including project management.
Education & Qualifications
* Essential: BSc or MSc in biochemistry, biotechnology or related discipline.
* Desirable: PhD in a related discipline.
Senior Scientist I Analytical Development – Oxford Immunocore (NASDAQ: IMCR) is a pioneering, commercial‑stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first‑in‑class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision‑engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognise that our employees are our greatest asset and expect the same level of commitment and dedication to our mission.
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