Overview
Research Associate - Mechanisms of G protein-coupled receptor (GPCR) activation (Fixed Term)
Research Associate position in the group of Prof. Daniel Nietlispach at the Department of Biochemistry, University of Cambridge. The project studies functional aspects of GPCR activation. The position is funded for 3 years by the BBSRC as part of a collaborative project to develop a molecular model of GPCR basal activity and inverse agonism, using structural biology and biophysics methods.
The investigations will be complemented through collaboration with the Ladds lab at the Department of Pharmacology (Cambridge), focusing on cellular aspects. You will join a team of postdocs and students and will lead your side of the project.
Responsibilities
* Design, conduct and interpret experiments in discussion with the PI, co-PI and other members of the research team.
* Perform structural and biophysical investigations of GPCR activation.
* Collaborate with the Ladds lab on cellular aspects of the project.
* Lead your side of the project within a team of postdocs and students.
Qualifications
* PhD in Biochemistry, Biophysics, Chemistry or another relevant subject.
* Proficiency in at least two of the following areas: (i) solution-state NMR spectroscopy, (ii) applied biophysics, (iii) computational modelling, (iv) membrane protein expression/purification and molecular biology.
* Active interest in GPCRs, membrane protein function or protein dynamics for receptor function is advantageous but not essential.
Employment details
* Fixed-term: funds available until 31 December 2028 (first instance).
* Apply online via the recruitment system.
* Informal enquiries: Professor Daniel Nietlispach at dn206@cam.ac.uk.
* Application process queries: Biochemistry HR Team via personnel@bioc.cam.ac.uk.
* Please quote reference PH47537 on your application and in correspondence about this vacancy.
* The University supports equality, diversity and inclusion and encourages applications from all sections of society. The University requires that all employees are eligible to live and work in the UK.
Seniority level
* Internship
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