Get AI-powered advice on this job and more exclusive features.
This range is provided by Northreach. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.
Base pay range
Direct message the job poster from Northreach
We are seeking an exceptional Scientist with a passion for immuno-oncology and hands-on expertise in CAR-T and TCR cell therapy discovery and development. This is a dynamic, lab-based role based at our Oxford site, where you will lead experimental design, execute in vitro functional assays, and collaborate cross-functionally to advance innovative cell therapies toward the clinic.
This position offers an exciting opportunity to contribute directly to the design and optimisation of novel CAR-T constructs within a fast-paced, collaborative biotech environment.
Key Responsibilities:
* Lead the design, development, and execution of in vitro functional assays to evaluate CAR-T/TCR activity, including cytotoxicity, cytokine release, and target engagement.
* Develop, optimise, and troubleshoot protocols for CAR construct screening and primary T cell engineering.
* Design and perform multiparameter flow cytometry experiments; analyse and interpret complex immunophenotyping data.
* Develop and validate ELISA and Western blot assays to support functional and mechanistic studies.
* Generate actionable insights from experimental data to guide CAR/TCR construct selection and refinement.
* Collaborate closely with bioinformatics, translational, and cell engineering teams to integrate data and align project goals.
* Prepare scientific presentations, technical reports, and contribute to regulatory documentation as needed.
* Stay abreast of emerging trends in CAR-T/TCR research and immuno-oncology; implement innovative approaches in R&D.
* Mentor junior scientists and foster a culture of scientific rigor, curiosity, and innovation.
Qualifications:
* PhD in Immunology, Molecular Biology, Cell Biology, or related discipline is required for Scientist level (Master’s with significant biotech experience considered for Senior RA role).
* Hands-on expertise in CAR-T/TCR development, T cell engineering, or immune cell therapy.
* Strong practical knowledge of multiparameter flow cytometry, ELISA, Western blot, assay development, and primary immune cell culture.
* Proven ability to analyse complex datasets and extract meaningful biological insights.
* Excellent scientific communication skills, both written and verbal.
* Ability to work independently and collaboratively in a fast-paced, team-oriented environment.
* Must be able to work on-site at our Oxford facility.
Why Join Us?
* Contribute to groundbreaking advances in next-generation cell therapy innovation.
* Work within a mission-driven, supportive, and collaborative scientific team.
* Opportunity to make a tangible impact on the future of immuno-oncology therapies.
If you are passionate about driving CAR-T/TCR therapy development and thrive in a fast-moving, impactful environment, and are able to work at our Oxford site, we encourage you to apply.
Seniority level
* Seniority level
Mid-Senior level
Employment type
* Employment type
Full-time
Job function
* Job function
Science
Referrals increase your chances of interviewing at Northreach by 2x
Sign in to set job alerts for “Scientist” roles.
Oxfordshire, England, United Kingdom 3 weeks ago
Oxfordshire, England, United Kingdom 3 weeks ago
Reading, England, United Kingdom 2 weeks ago
Oxford, England, United Kingdom 1 day ago
Abingdon-On-Thames, England, United Kingdom 1 week ago
Oxford, England, United Kingdom 3 weeks ago
Specialist Biomedical Scientist (Dissection)
Oxford, England, United Kingdom 1 day ago
Oxford, England, United Kingdom 6 days ago
Oxfordshire, England, United Kingdom 2 weeks ago
Reading, England, United Kingdom 2 weeks ago
Oxford, England, United Kingdom 1 week ago
Witney, England, United Kingdom 2 weeks ago
Oxford, England, United Kingdom 1 week ago
Oxfordshire, England, United Kingdom 5 days ago
Scientist, Clinical Biomarker Laboratory, Immuno-assays (cell based)
Oxford, England, United Kingdom 1 week ago
Oxford, England, United Kingdom 1 week ago
Scientist Analytical Development & Validation
Oxford, England, United Kingdom 1 week ago
Abingdon-On-Thames, England, United Kingdom 1 week ago
Associate Scientist Analytical Development
Oxford, England, United Kingdom 2 weeks ago
Oxford, England, United Kingdom 1 week ago
Witney, England, United Kingdom 1 week ago
Didcot, England, United Kingdom 3 weeks ago
Scientist, Quantum Sensing (Magnetometry)
Oxford, England, United Kingdom 3 weeks ago
Oxford, England, United Kingdom 4 days ago
Principal Scientist – Semi-Solid-State Batteries
Oxfordshire, England, United Kingdom 2 weeks ago
Reading, England, United Kingdom 4 days ago
Witney, England, United Kingdom 1 month ago
Oxford, England, United Kingdom 1 week ago
Oxford, England, United Kingdom 3 weeks ago
Operations Scientist - Environmental Monitoring Group
Witney, England, United Kingdom 1 week ago
Oxford, England, United Kingdom 1 day ago
Biomedical Scientist Blood Transfusion Lead
Oxford, England, United Kingdom 5 days ago
Senior Biomedical Scientist - Dissection Lead
Oxford, England, United Kingdom 2 weeks ago
Principal Scientist I Analytical Development
Oxford, England, United Kingdom 2 weeks ago
Abingdon-On-Thames, England, United Kingdom 2 weeks ago
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
#J-18808-Ljbffr