Nuffield Department of Clinical Neurosciences (NDCN), John Radcliffe Hospital, Headington, Oxford, OX3 9DU
This is an exciting opportunity for a highly motivated Post-Doctoral Research Assistant to join the Inflammatory Neuropathy Research Group within the Nuffield Department of Clinical Neurosciences (NDCN), University of Oxford. The post is funded by GBS|CIDP Foundation International as part of a translational research programme entitled "Decoding and monitoring the immunology of multifocal motor neuropathy to guide next-generation, disease-modifying therapies".
The overall aim of the project is to define and track the pathogenic B-cell clones and autoantibodies driving multifocal motor neuropathy (MMN), and to use this knowledge to inform targeted, disease-modifying therapeutic strategies. The project integrates advanced immunophenotyping, single-cell approaches, B-cell receptor sequencing, antibody cloning, in vitro functional assays (including human iPSC-derived motor neuron systems), and longitudinal immune monitoring.
The post-holder will work under the joint supervision of Prof Simon Rinaldi (Oxford) and Dr Nicolas Dubuisson (Oxford/UCLouvain). The first 18 months will be based in Oxford, focusing on detection and characterisation of pathogenic B-cell clones and antibody cloning. The remaining 18 months will be spent at UCLouvain (Belgium), developing downstream antibody production, characterisation, and therapeutic testing pipelines, while remaining employed by the University of Oxford.
The post offers an outstanding opportunity to contribute to a high-impact translational programme, develop independent scientific expertise in autoimmune neurology and B-cell immunology, and gain experience across two leading European centres.
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