Senior Scientist (DMPK)
Department: Therapeutic Innovation, R&I
Reports to: Group Leader
Location: Babraham Research Campus, Cambridge (Hybrid – minimum 3 days per week on-site)
Contract type: 1-year Fixed Term Contract
Hours: Full time, 35 hours per week
Closing date: Tuesday 21st April 23:55pm
£41,700 - £48,400 plus benefits
As a Senior Scientist in DMPK, you will play a key role in advancing both small- and large-molecule programs from lead optimization through candidate selection. The successful candidate will apply deep technical expertise in pharmacokinetics, metabolism, and quantitative modelling to support the design and execution of translational strategies across therapeutic areas. Reporting directly to the DMPK Group lead, you will work closely with the medicinal chemistry team and more widely with cross‑functional teams, seeking to accelerate novel therapies into clinical development.
Responsibilities
* Develop an appropriate DMPK screening cascade aligned with project stage and objectives.
* Design, execute and interpret ADME assays, and communicate results clearly and accurately to project team members.
* Oversee CRO activities, including submitting compounds for assays, tracking ongoing experiments, and communicating data updates to the team.
* Prepare and regularly update slide decks and other documentation to summarise CRO data and project progress; manage purchase orders and invoicing related to CRO activities.
* Maintain accurate, complete and up‑to‑date electronic laboratory notebooks in compliance with internal standards.
* Perform LC‑MS/MS analyses for small and large molecules, including routine maintenance and basic troubleshooting of instruments.
* Keep abreast of state‑of‑the‑art DMPK technologies and developments in cancer therapeutics, and apply new knowledge to ongoing projects where appropriate.
* Knowledge of PK‑PD /PBPK modelling and human dose prediction would be an asset to the projects.
Qualifications
* Qualified to PhD or BSc/MSc with relevant experience in a life sciences discipline and industrial drug discovery experience.
* Practical knowledge of in vitro ADME assays including microsomal stability, hepatocyte stability, protein binding and permeability.
* Knowledge and prior experience of using Phoenix WinNonlin.
* Knowledge and prior experience of metabolite identification.
* Practical experience of bioanalysis by LC‑MS/MS is essential (desirable).
* Knowledge and prior experience of using MassLynx and UNIFI (desirable).
* Good time management skills, a proven ability to form close and effective relationships with colleagues at all levels and excellent written and verbal communication skills.
Benefits
We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high‑quality tools. Our policies and processes enable you to improve your work‑life balance, take positive steps in your career and achieve your personal wellbeing goals.
We are unable to recruit applicants below the age of 18 to protect young people from health & safety and safeguarding risks.
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