Overview
Biotage – Southampton, United Kingdom. Senior Scientist – SME Mass Spectrometry in the Oligonucleotide Production Department, Southampton. Lead analytical strategy and contribute to the development and production of high-quality modified oligonucleotides.
Responsibilities
* Lead and oversee analytical workflows involving LC-MS, HPLC, PAGE, UPLC-MS and related chromatography to support oligonucleotide synthesis and purification.
* Act as the subject matter expert (SME) in Mass Spectrometry, driving method development, troubleshooting, and continuous improvement initiatives.
* Collaborate cross-functionally to optimize small molecule preparation and oligonucleotide synthesis processes.
* Maintain and calibrate analytical instrumentation, ensuring high performance and compliance with quality standards.
* Provide technical leadership and mentorship to Associate Scientists and Lab Technicians, supporting training and development.
* Ensure rigorous documentation and data integrity in line with ISO and internal quality systems.
* Champion Health, Safety, and Environmental (HSE) standards and promote a culture of safety and compliance.
* Manage inventory and procurement of analytical reagents and consumables.
* Stay abreast of emerging technologies and methodologies in nucleic acid chemistry and analytical science.
Qualifications
* PhD in Chemistry, Analytical Chemistry, or a related discipline.
* Proven experience in a high-throughput chemistry or oligonucleotide production environment.
* Extensive hands-on experience with Mass Spectrometry, ideally including Waters LC-MS systems (Experience of Waters Connect is highly desirable).
* Strong background in nucleic acid chemistry and familiarity with purification techniques. Oligonucleotide experience is highly desirable.
* Demonstrated ability to lead projects, mentor junior staff, and influence scientific strategy.
* Experience working within ISO or GMP-regulated environments.
* Excellent problem-solving, communication, and organizational skills.
* Self-starter with ability to work under pressure in a fast-changing environment, detail-oriented with strong communication skills.
What we can offer
* 25 days annual leave plus 8 paid bank holidays
* Contributory pension scheme (6% employer contribution)
* Flexible working hours
* Life Assurance (x4 salary)
* Long service awards
* Reward and recognition scheme
* Employer Assistance Programme with 24/7 remote GP service
* Annual flu jabs
* Cycle to work scheme
* Corporate discount on gym membership
* Savings and discounts
* Reimbursement of professional membership fees
* Referral incentives
* Social events
* Volunteering days
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