At Cancer Research UK, we exist to beat cancer
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At Cancer Research Horizons (CRH) our Therapeutic Innovation team is investing in a world‑leading capability to translate breakthrough discovery science into the next generation of oncology therapeutics. As part of this evolution, we are establishing a new Network Translation team. A group of experienced oncology drug discoverers dedicated to identifying, shaping, and accelerating the most exciting science emerging from the CRUK research ecosystem. Every role at CRH is united by a single mission: beating cancer sooner. We carry out work that matters - impacting patients, families, and the future of science
As a Senior Principal Scientist, you will play a pivotal role in evaluating the breadth of CRUK’s research portfolio, as well as emerging scientific areas with strong therapeutic potential. Working across CRUK Institutes, Centres, and international academic collaborations, you will build trusted relationships with scientific leaders to uncover early‑stage ideas with the potential to become validated, fundable therapeutic concepts.
This is an outward‑facing, high‑visibility role that requires deep scientific insight, strategic judgement, and a natural curiosity for uncovering translational opportunity before it becomes obvious. You will help transform breakthrough biology into new medicines for cancer patients, shaping not only individual projects, but the future direction of CRUK‑funded oncology research itself.
This position offers a rare opportunity for an accomplished drug hunter to influence therapeutic innovation on a national scale and support the discovery of tomorrow’s cancer therapies. You’ll be joining over 200 staff across CRH from both industrial and academic backgrounds, all dedicated to bringing forward the day we cure cancer.
What will you be doing?
1. Support the implementation of a new Network Translation strategy for CRH TI to enhance the number of therapeutic opportunities identified from CRUK funded research.
2. Maintain awareness of emerging areas of cancer biology and technological advances relevant to the objectives of CRH TI in order to identify and recommend priority translational opportunities for examination or investment.
3. Analyse current and future CRUK funded research to highlight key translational opportunities.
4. Work with CRUK PIs, Research Institutes and Centres, within the UK and internationally (CRUK/NCI Grand Challenges or Academic Alliances) to identify translational opportunities.
5. Perform detailed reviews of opportunities identified.
6. Shape new hypotheses and collaborative proposals in partnership with PIs.
7. Signpost the Therapeutic Catalyst scheme and assist the development and submission of EOI proposals.
8. Propose translational opportunities for strategic interventional funding.
9. Propose opportunities for consideration as TI collaborations and for experimental validation by TI’s Portfolio Generation.
10. Promote the visibility of the Network Translation team in the academic research community and life science sector.
What are we looking for?
11. PhD or equivalent in a relevant discipline (e.g. Bioscience, Chemical Biology) with previous experience of working on oncology drug discovery in industry.
12. You will have expertise in identifying and developing small molecule therapies and/or biotherapeutics, with an awareness of alternative therapeutic modalities.
13. A good understanding of mechanistic cancer biology, current therapeutic approaches in oncology, and personalised medicine strategies applied to cancer treatment.
14. A good understanding of translating opportunities from a target concept to a therapeutic, including relevant target validation methods and the use of preclinical models.
15. Previous experience of working productively with or within the academic sector on translational/therapeutic projects.
16. Knowledge of the broad drug development pipeline, from Target Identification through to clinical development.
17. Excellent interpersonal skills with the ability to network and build strong working relationships.
18. Excellent written and verbal communication skills.
19. Strong and collaborative team player.
20. Self-motivated individual with excellent time-management skills, able to prioritise workload and deliver to tight deadlines.
Our organisation values are designed to guide all that we do.
Bold: Act with ambition, courage and determination
Credible: Act with rigour and professionalism
Human: Act to have a positive impact on people
Together: Act inclusively and collaboratively
We’re looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.
If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience, we’d still love to hear from you.
What will I gain?
We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance and take positive steps in your career.
You can explore our benefits by visiting our careers web page.
How do I apply?
We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won’t be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.