Overview
Why this role is important for CPI’s
work
CPI has an exciting opportunity for an experienced scientist to join its dynamic, analytical team within the in Darlington to support cutting-edge biopharmaceutical innovation across platforms including mRNA vaccines, AAV vectors, monoclonal antibodies, and recombinant proteins.
This role offers the opportunity to contribute to impactful projects such as Fortuna 5 (AAV) and Electra (protein), applying analytical expertise to characterise complex biologics and support process development. It is also offers the chance to work across avariety of analytical techniques, some of which may include: high-performance liquid chromatography (UPLC / HPLC), mass spectrometry, capillary isoelectric focusing, biolayer interferometry, dynamic light scattering, differential scanning calorimetry, circular dichroism, capillary electrophoresis, ELISA, polymerase chain reaction techniques (qPCR and ddPCR), microfluidic imaging, SEC-MALS and SDS-PAGE.
The Role
Key tasks in the role will include (but are not limited to the below):
* Interpreting and reporting on experimental data to internal and external stakeholders
* Maintaining GMP and Data Integrity compliance across all analytical activities
* Supporting business development through technical input and client engagement
* Collaborating across teams to deliver project milestones and continuous improvement
* Providing mentoring and training to junior team members
* Maintaining and calibrating analytical equipment to ensure operational readiness
The successful candidate will have the opportunity to support avariety of projects, where analytical work packages can include :
* Designing, verifying, and applying analytical methods for biopharmaceutical characterisation
* Monitoring residuals and impurities, to support bioprocess development (e.g. host-cell proteins, residual DNA, RNA, and endotoxins)
* Molecule characterisation to Identify critical quality attributes and molecule heterogeneity
* Investigate stability (e.g. fragmentation, aggregation, solubility, particle formation)
* Accelerated stability / forced degradation studies
* Understand degradation pathways
* Develop stability indicating assays
* Support formulation development
* Identify critical quality attributes
The Person
The person we are seeking
The Person
The successful candidate will be educated to a minimum of HNC / Foundation Degree level (or equivalent) in a Scientific / Engineering discipline with industrial experience and;
* Be experienced in analytical techniques for biologics characterisation and problem-solving in some of the following techniques: high performance liquid chromatography (UPLC / HPLC), mass spectrometry, capillary isoelectric focusing, biolayer interferometry, dynamic light scattering, differential scanning calorimetry, circular dichroism, capillary electrophoresis, ELISA, polymerase chain reaction techniques (qPCR and ddPCR), microfluidic imaging, SEC-MALS and SDS-PAGE
* Have an understanding of GMP and / or Data Integrity principles
* Be able to demonstrate the ability to work independently and collaboratively across multidisciplinary teams
* Be an effective communicator with experience in data presentation and documentation
It would be great if you had one or more of the following :
* Membership of a relevant professional body
* Experience mentoring or training others
* Familiarity with statistical analysis, QbD / DoE and application to experimental design, and scientific software tools
* Familiarity with high-throughput screening using automated liquid handling systems.
What does CPI offer you?
At CPI, we offer a wide range of benefits to our employees, this includes :
* Up to 36 days holiday, including bank holidays – Plus a holiday purchasing scheme
* Generous pension scheme
* Life assurance and accident insurance schemes
* Flexible working
* Learning and Development Opportunities
* Free parking
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