Senior Manager – Real‑World Evidence (RWE) Generation
12‑month contract | Hybrid working
A global life sciences organisation is seeking a Senior Manager specialising in Real‑World Evidence Generation to support the development of high‑quality observational research within its Medical Affairs function. This role supports evidence needs across several complex therapy areas and plays a key part in shaping data‑driven medical strategy.
We are looking for someone who combines scientific depth with strong applied experience in epidemiology, observational study methods, and real‑world data analysis.
About the Role
You will contribute to the development, execution, and interpretation of real‑world evidence studies, partnering closely with cross‑functional teams including Clinical, Regulatory, Safety, Insights and Market Access. The position involves designing observational study concepts, guiding analytical approaches, and translating results into actionable insights for internal and external stakeholders.
This is a hands‑on scientific role suited to someone who enjoys both methodological work and medical‑affairs‑aligned evidence strategy.
Key Responsibilities
* Develop and refine study concepts such as incidence, prevalence, burden‑of‑illness and natural‑history research.
* Provide operational and scientific support for real‑world evidence projects, including registries and post‑authorisation‑aligned research.
* Contribute to methodological strategies, including historical control approaches and other observational study designs.
* Create and maintain dashboards, metrics and tracking tools for RWE projects.
* Write and review study documentation: protocols, SAPs, study reports and related materials.
* Translate complex analytical results into clear messages for internal teams and external experts.
* Support evidence contributions for regulatory or health‑technology‑related interactions.
* Engage with investigators, advisory groups, scientific leaders and cross‑functional project teams.
Essential Qualifications
* Scientific degree (e.g., MSc, PhD, MD, PharmD or equivalent).
* Background in epidemiology, biostatistics, outcomes research or a closely related field.
* Experience in observational research design and real‑world evidence generation.
* Ability to interpret analytical outputs and provide scientifically rigorous insight.
* Strong communication skills with the ability to adapt messages to technical and non‑technical audiences.
* Familiarity with statistical tools (e.g., R, SAS, SPSS, Stata).
Preferred Experience
* PhD in epidemiology, biostatistics, HEOR or health services research.
* Experience working with complex therapy areas (e.g., immunology, oncology, rare diseases or chronic conditions).
* Exposure to post‑authorisation or post‑launch evidence requirements.
* Experience conducting or reviewing systematic literature reviews.
* Strong publication experience or scientific writing background.
* Ability to work effectively within a dynamic, matrixed environment.