The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our major strength in understanding the immune systems of livestock provides a platform to control current diseases and respond to emerging threats. This important research would not be possible without the proportionate use of animals, which are integral to the development of new disease control measures such as vaccines and diagnostics. We have an establishment-wide commitment to the 3Rs (replacement, reduction, and refinement), high standards of animal welfare, a culture of care and openness.
Our Institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds and experience. We all play a crucial role in furthering the Institute’s aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; with a real focus in improving the world in which we live. Our outlook is always balanced by our strong sense of purpose, values and behaviours and an unwavering commitment to a ‘one Institute’ approach.
About the Viral Oncogenesis Group
Applications are invited to join the Viral Oncogenesis group at Pirbright Institute and report to the Head of the group. Our research has focused on investigation of host/virus interactions to unravel the molecular mechanisms of tumour formation by avian oncogenic viruses using state-of-the-art technologies including reverse genetics on viral genomes, CRISPR/Cas9 editing, global CRISPR screening, CRISPRi/CRISPRa tools, bioimaging technologies and animal infection model. The purpose of this position is to work on ‘Transmissible vaccines on disease ecology and pathogen evolution’, a collaborative project with Penn State University. We are looking for highly motivated virologist to deliver the milestones of the project.
The successful candidate will be required to manage the objectives of the international collaborative research project examining the role of transmissible vaccines on virus evolution dynamics using established experimental infection models. Working independently and in liaison with members of the team and other research groups, the position offers the opportunity to become a pivotal member of the team striving to bring innovation through high-impact research. The postholder will also have the prospects of working with the Head of the Group in management duties and supervision of students.
All employees shall actively participate in the Institute-wide quality assurance system in conjunction with the Institute’s Quality Manager. Employees are also expected to safeguard their own health and safety and security by following policies and all employees are responsible for the Health and Safety and security of staff under their management.
Main duties and responsibilities:
* The post-holder will carry out research to meet the research project objectives of exploring models of transmissible vaccination to identify knowledge gaps in transmission dynamics and virus evolution.
* Be responsible for driving the project, contributing to experimental design and data analysis.
* Dealing with problems that may affect the achievement of research objectives and deadlines.
* Contribute to developing new models, techniques and methods.
* Contributing and helping to develop innovative research projects for securing additional funding.
* Generating high impact research publications based on the findings from the research projects.
* Prepare regular brief reports for collaborators and contribute to video conference and in person discussions with collaborators.
* Supporting senior colleagues to enhance the international impact of the Institute by participation in meetings, joint projects and other activities.
* Assisting in Laboratory management responsibilities (ordering, looking after equipment, maintenance, sample inventories) and animal experiments under the Project Licence managed by the group.
* Contributing towards the Knowledge exchange, business development and outreach programmes of the Institute.
* Participate in the operational and academic management activities.
* Interact with other members of the group as well as other groups on wider aspects of research innovations into the control of avian viral diseases.
Due to the nature of the work we do, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances.
Essential/Desirable requirements
* PhD degree in virology, cell biology, another relevant field of biology or equivalent
* Strong foundational understanding of herpesvirus virology
* Proven experience in specialized molecular virology techniques such as reverse genetics through BAC mutagenesis and/or CRISPR/Cas9 genome editing
* Good track record of publications in a relevant field, commensurate with the level of experience
* Proven experience on nanobody generation including protein expression, purification, screening and characterization
* Demonstrated hands-on experience working on the application and use of herpesvirus mutagenesis techniques in research
* Proven track record of networking skills with the ability to build effective collaborative relationships
* Proven track record in managing/supervising staff/students
What we offer
* Generous Group Personal Pension Scheme and life cover (subject to age and earnings)
* 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days
* Buy and sell annual leave
* Option to carry over up to two weeks annual leave
* Pirbright gym with subsidised membership
* Pirbright social club
* Pirbright Lifestyle Hub (employee discount site)
* Cycle to work
* Subsidised employee restaurant
* Childcare allowance
* Free onsite parking
* Electric car charging facilities
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