Grade UE07: £41,064 - £48,822 per annum pro-rata if part-time
College of Medicine and Veterinary Medicine / Clinical Sciences / Institute for Regeneration and Repair / Centre for Inflammation Research
Full-time: 35 hours per week
Fixed-term: for 2 years
We are looking for a Postdoctoral Research Fellow studying renal senescence and fibrosis signalling using in vitro and in vivo models of aging and disease. The post will be based in the Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh with Professor David Ferenbach.
This post is advertised as full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns.
The Opportunity:
This fellowship forms part of a MRC-funded Senior Clinical Fellowship, based in the Institute for Regeneration and Repair – home to over 1000 research staff and students. Its focus is on the identification of novel pathways linking senescent epithelia to tissue fibrosis in human chronic kidney disease. The post holder will lead the validation of these pathways using advanced cell culture approaches to interrogate the interactions between healthy and senescent renal epithelia and renal leukocytes and fibroblasts. Further work will explore the potential for these pathways to be targeted in vivo to promote senescent cell clearance and prevent senescent cell accumulation with ageing and tissue injury.
Your skills and attributes for success:
PhD or equivalent (or will be shortly awarded a PhD) in biological sciences.
Experience of in vivo work, ideally including models of renal injury and fibrosis.
Experience of in vitro work, ideally working with models of epithelial cell culture ± co-culture.
Experience of a several biological assays for determining mechanisms, e.g., several of: histology, light or fluorescent microscopy, absorbance assays, ELISA, flow cytometry, DNA/RNA extraction, qPCR.
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