About the role Applications are invited for a Postdoctoral Research Associate in Organic Chemistry to work under the supervision of Professor Yimon Aye for a period of up to 12 months. The project involves chemical synthesis of selective small-molecule inhibitors targeting proteins/pathways essential in oxidative stress-associated disease states including cancer, neurodegeneration, cardiovascular, and immune system disorders. The postdoctoral researcher will synthesise highly selective inhibitors based off successful lead compounds that we recently discovered, guided further (where applicable) by computational docking and/or AI-assisted predictive tools. All molecules will be screened using in vitro and cell-based platforms established in our team, and the best will be continued to more advanced models. There is possibility for the postdoctoral researcher to learn cutting-edge functional assay technologies, in line with their interest to diversify and successful and timely production of desired molecules (and subsequent SAR). Find out more about the Aye research and group at: https://www.chem.ox.ac.uk/people/yimon-aye About you Applicants should hold (or be close to holding) a PhD in Organic or Medicinal Chemistry prior to taking up the appointment. Ideal candidates should have a broad experience with functional groups, diverse synthetic routes, and work in both small- and large-scale experiments. Use of NMR (1 and 2D, nOe, etc.), and LC/GC-MS is a must for adequate compound characterisation. A supple mindset and willingness to focus on production over elegance is likely a must. Experience with some in vitro biochemical procedures is a bonus, but is not required. You will be expected to manage your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. The post will be based in the Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA and Rodney Porter Building, Sibthorp Road, off South Parks Road, Oxford, OX1 and is available from January 2026. Application Process Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your application. In your supporting statement (, please explain how you meet each of the selection criteria found in the job description. Certificates, references and research papers should not be provided at this stage. The closing date for applications is 12.00 midday, Friday, 23rd January 2026, UK time. Interviews will be held on as soon as possible thereafter. The University of Oxford and The Department of Chemistry are Silver Athena SWAN holders. Applications are particularly welcome from women and black and ethnic minority candidates, who are under-represented in Chemistry research posts in Oxford.