Job Title:
Scientist – Tissue Handling
Employment Type: 12 month Contract
Location: London, UK - 100% Lab based
The Role:
We are seeking a highly motivated Scientist / Recent Ph.D Graduate with a background in Molecular Biology, Cell Biology, or a related field. The ideal candidate will have experience in spatial transcriptomics and proteomics, particularly using FFPE tissue samples, and a strong background in 10X Genomics library preparation for NGS.
You’ll work in a fast-paced, collaborative environment, driving the development and optimization of cutting-edge spatial omics workflows in support of translational research and clinical discovery.
Key Responsibilities:
* Design, execute, and troubleshoot experiments using 10X Genomics Visium and related platforms for spatial transcriptomics.
* Process and analyze FFPE and fresh frozen tissue samples for transcriptomic and proteomic profiling.
* Prepare high-quality NGS libraries for Illumina sequencing, ensuring data integrity and reproducibility.
* Optimize protocols and workflows for challenging tissues (e.g., fibrotic, adipose, cartilage, bone).
* Collaborate with bioinformaticians, pathologists, and clinical researchers to interpret spatial omics data.
* Maintain accurate records, contribute to publications, and present findings at internal and external meetings.
Required Qualifications:
* Ph.D. in Molecular Biology, Cell Biology, Biotechnology, or related discipline with a focus on spatial transcriptomics or proteomics.
* Proven experience handling FFPE tissues for transcriptomic and protein-based methods.
* Expertise in 10X Genomics library preparation and workflows for NGS (e.g., Chromium, Visium).
* Familiarity with Illumina sequencing platforms and general NGS QC metrics.
* Experience working with difficult tissue types such as fibrotic, adipose, cartilage, or bone.
* Hands-on experience in single-cell technologies (e.g., scRNA-seq, CITE-seq) is a strong plus.
Preferred Skills:
* Strong understanding of tissue processing, histology, and immunostaining techniques.
* Excellent organizational and communication skills.
* Ability to work both independently and within cross-functional teams.
What We Offer:
* Competitive salary and benefits package.
* Access to state-of-the-art facilities and research platforms.
* Opportunities for professional development and international collaboration.
* A dynamic and inclusive working environment that supports innovation and curiosity.