About Level Zero
Level Zero is pioneering next-generation biosensor technology for precise, real-time monitoring of critical endocrine biomarkers. Recognised as one of the top 20 startups across all categories worldwide at TechCrunch Disrupt 2024—and backed by top-tier organisations like SOSV and Entrepreneur First—we’re pushing the boundaries of biochemistry and nanotechnology to revolutionize personalised health.
Founded by two seasoned engineers, we bring extensive experience in R&D, technical innovation, and commercial strategy to transform the way people monitor their health. Our mission is bold: to revolutionise health management by delivering clinical-grade data directly to individuals, wherever they are.
We’re seeking driven innovators to join us in pushing the boundaries of biosensing and health tech, making personalised health monitoring a reality for everyone. To achieve this ambitious vision, we’re assembling the best team in the world—dedicated to turning cutting-edge science into life-changing, real-world solutions.
About The Role
We are excited to welcome a aptamer scientist to join our team. The ideal candidate will have expertise in SELEX, aptamer library design, and binding analysis using techniques like SPR and BLI. Proficiency in bio-conjugation reactions, nucleic acid structure characterization. Strong data analysis skills with tools like Python or R are required. Experience with electrochemical aptamer-based biosensors is a plus. The candidate will work closely with the nano-biosensor team to advance R&D milestones.
This is a full-time, in-person role primarily based in London.
Some examples of what you might do:
* Design Library for aptamer selection against various small molecule or proteins
* Wet lab experiments to perform selections, identification and binding analysis of candidates using fluorescence, electrochemical based method, or biophysical techniques such as Surface plasmon / Biolayer interferometry
* Perform various bio-conjugation reactions and purifications of oligonucleotides
Analyse and organise raw experimental data as technical reports.
* Work closely with the Nano biosensor team leader for work progress towards R&D milestones
* Attend R&D-related trainings and seminars for continuous updates on the latest trend in small molecule sensing technologies
What You Bring
* A Ph.D. in Molecular Biology, Biochemistry, Nucleic Acid Chemistry, or a related field. Postdoctoral experience (university or industrial) will be a plus for this position
The ideal candidate will possess expertise in the following areas:
* Proficient in Capture-SELEX, including library and primer design, optimisation of regeneration of libraries
* Skilled in molecular biology techniques, including RT-PCR, cloning, in vitro transcription, and various gel electrophoresis (denaturing, native PAGE and agarose)
* In-depth knowledge of fluorescence-based assays, such as fluorescence resonance energy transfer (FRET) and other fluorescence detection methods. Experience with standard gel scanning instruments such TYPHOON or Geldoc etc
* Experience with Nucleic Acid secondary structure characterisation by biophysical and biochemical techniques such as CD Spectroscopy, DMS Footprint, SHAPE assays
* Extensive experience with high-throughput sequencing and bioinformatics workflows for aptamer characterisation
* Well-versed in DNA/RNA folding, secondary structure prediction, and basic computational analysis tools
* Experience with display-based selection methods, such as bead-based, droplet-based, or cell-based platforms for aptamer screening
* Hands on experience of basic conjugation chemistries like NHS coupling, Click chemistry and solid phase oligo synthesis
Nice to have:
* Experience with Electrochemical/optical Aptamer based biosensor development
* Operating ability and basic analytical knowledge of standard instrument such as HPLC, FPLC, and LC-MS
Who You Are
* We value culture as much as we value technical expertise, creating an environment that’s equal parts collaboration, curiosity, and fun
We’re a fast-paced, mission-driven young team on a quest to make a lasting impact, fueled by uncompromising integrity, unwavering support for one another, and the thrill of exploring uncharted territories. Our passion for excellence drives everything we do, and we welcome individuals who share our commitment to shaping the future.
If our vision excites you, here are the qualities we look for:
* You live and breathe integrity, tackling challenges with honesty and transparency
* You’re a self-starter who loves diving into the unknown, collaborating on complex problems, and taking full ownership of results
* You excel at open, clear communication and see every piece of feedback as a springboard for growth—especially in a science and data-focused environment
* You’re motivated by creating real impact, particularly when it comes to advancing human health
* You strike a balance between independence and collaboration, knowing when to seek support or invite others to join in
* You’re confident in defending your ideas, while also valuing respectful, constructive debate as a path to better solutions
* You thrive in the dynamic atmosphere of a startup, constantly evolving your skill set and fearlessly applying what you learn
What We Offer
* A full-time role with a competitive salary and equity options, reflecting our value in your expertise and potential
* An environment where you’ll collaborate directly with the founding team at a leading biosensor startup, gaining access to industry experts and thought leaders
* The chance to grow with us, including ample opportunities for leadership, career advancement, and exploration
* Travel to New York and other potential sites for R&D purposes
* The excitement of working on cutting-edge technology, shaping strategic decisions, and driving innovation at an early-stage venture alongside a superstar team
Be Part of Our Journey
If you're ready to be at the forefront of biosensing innovation and thrive in fast-paced, learning-rich environments, we'd love to hear from you.
If your skills and experience do not align perfectly with this role, yet you believe you have something unique to offer, we're keen to listen. Reach out to us with a short statement on how you can contribute and let's discuss where you might fit into our team.
Seniority level
* Seniority level
Not Applicable
Employment type
* Employment type
Full-time
Job function
* Job function
Research, Analyst, and Information Technology
* Industries
Software Development
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