About the role
The post-holder will be expected to perform the highest quality research under the direction of the Principal Investigator, and to work effectively with internal and external collaborators involved in the project and other group members.
The successful candidate will play a key role in uncovering the molecular mechanisms that govern the development and function of thymic epithelial stem cells, with a focus on the role of transcriptional regulation in medullary cell fate decisions. Building on our recent findings, the project aims to define how specific transcriptional programs drive the differentiation of these epithelial lineages and shape the thymic microenvironment. The candidate will investigate how disruptions in these regulatory networks may impair tolerance and contribute to the onset of autoimmune disease by using in vitro models and assays as well as novel mouse models. The successful candidate will be expected to undertake independent high-quality molecular analyses in both systems. In parallel, the researcher will explore alterations in thymic epithelial composition in pathological contexts such as autoimmunity and tumours. By clarifying how altered epithelial subtypes affect immune regulation, the findings will support the development of improved diagnostic tools and selective therapeutic strategies. The successful applicant will join a collaborative, cross-disciplinary team at the interface of developmental immunology, epithelial biology, and clinical research.
The successful candidate will also be expected to generate, analyse, and present scientific findings from the work undertaken to a broad range of audiences, both internal and external to UCL and the Crick.
The position is available for 2 years in the first instance. The position may be extended, dependent on project success, funding, and scientific priorities. The position will suit a motivated postdoctoral scientist who enjoys working as part of a multidisciplinary team and wishes to develop their career and pursue opportunities for independent fellowships.
About you
The successful applicant should have a PhD or equivalent (or soon to be awarded) in Biology/Biomedical Sciences or a related subject and have significant experience working in a research laboratory.
A high level of attention to detail and a proven commitment to scientific excellence are essential. Competency in molecular biology and animal models are essential. Molecular biology experience includes wet and dry lab RNA sequencing and data analysis skills.
Candidates must have a track record of showing important contributions to research, excellent oral and written scientific communications skills, commitment to collaboration in research and to taking a multidisciplinary approach to problem solving. They must be highly organised, able to manage their time and work to strict deadlines. They must be able to deal pleasantly and effectively with a wide range of people and keep accurate and detailed written laboratory records.
Note: Appointment at grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at the Research Assistant Grade 6B (salary £38,- £41, per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.
Informal enquiries regarding the vacancy can be made by email to Prof. Paola Bonfanti or .
Please see the attached job description and person specification for full details. Please also read the attached Candidate Guidance document.
All applications must include a supporting statement, telling us, using examples, how you meet the essential criteria listed in the job description. Applications without a supporting statement will be rejected.
If you have any queries about the role or application process, technical issues, or need reasonable adjustments or a more accessible format to apply for this job online, please contact the staffing team at .
What we offer
As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below:
1. 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
2. Additional 5 days’ annual leave purchase scheme
3. Defined benefit career average revalued earnings pension scheme (CARE)
4. Cycle to work scheme and season ticket loan
5. Immigration loan
6. Relocation scheme for certain posts
7. On-Site nursery
8. On-site gym
9. Enhanced maternity, paternity and adoption pay
10. Employee assistance programme: Staff Support Service
11. Discounted medical insurance