Overview
A Research Assistant position is available in the group of Prof. Walid T. Khaled at the Department of Pharmacology and Cambridge Stem Cell Institute, University of Cambridge. This position is part of PreBRCATx, a major new project funded by the European Research Council (ERC), focused on developing therapeutic interventions to prevent hereditary breast cancer. Building on the Khaled Lab's expertise in tumour initiation and early transformation, this project aims to intercept breast cancer before it starts, with a particular focus on individuals carrying high-risk mutations in BRCA1, BRCA2, and PALB2. Through advanced single cell genomics, in vivo modelling, and immune profiling, the team will study early molecular and cellular changes that occur in high-risk breast tissue. The team will test the ability of known and near-clinical drugs to reverse or block these changes and ultimately aims to develop a preventive breast cancer vaccine for individuals with inherited predisposition. This role offers a rare opportunity to contribute to cancer interception science at the frontier of personalised prevention, with strong translational potential.
Responsibilities
* Maintain GEMM colonies and perform in vivo experiments as required by the project.
* Collect and analyze data generated from in vivo studies and sequencing/immune profiling experiments.
* Communicate results effectively, be organised, and keep detailed records.
Qualifications
* BSc degree in biological sciences with demonstrable experience working with GEMMs (genetically engineered mouse models).
* Active Personal Identification Licence (PIL) is essential for in vivo work.
* Effective communication, good organisational skills, and meticulous record-keeping.
Employment details
* Fixed-term: 24 months in the first instance (funded by ERC) subject to a probation period and performance review.
* Please upload a covering letter detailing relevant experience, a CV, and the names and contact details of two referees (one should be your most recent line manager).
* Only requested documents will be considered; unrelated documents will not be reviewed.
Application process and contact
Click the Apply button to register an account and apply online. Informal enquiries should be addressed to Professor Walid T. Khaled (wtk22@cam.ac.uk). For online application process inquiries, contact the HR Team (hr@phar.cam.ac.uk). Please quote reference PL47143 in your application and correspondence. The University supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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